FRAX — Know Your 10-Year Fracture Risk|骨活ガイド
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FRAX — Know Your 10-Year Fracture Risk

A step-by-step guide to the WHO fracture risk calculator, walking you through each input and helping you understand your results.

Knowing your bone density is important, but it is only part of the picture. Two people with the same DXA score can have very different fracture risks depending on their age, medical history, and lifestyle. That is where FRAX comes in -- a tool that brings all of these factors together into a personalized fracture risk estimate.

If your doctor has mentioned FRAX, or if you want to understand your own fracture risk more clearly, this article walks you through exactly how it works.

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What you'll learn on this page

  • What FRAX is and who developed it
  • How to use the FRAX calculator (step by step)
  • What the results mean
  • When treatment is typically recommended based on FRAX scores
  • Important limitations to keep in mind
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What is FRAX?

FRAX (Fracture Risk Assessment Tool) is a computer-based algorithm developed by the World Health Organization (WHO) Collaborating Centre at the University of Sheffield, UK. First released in 2008, it has been calibrated for use in over 70 countries and is available in multiple languages.

FRAX calculates two numbers:

  1. Your 10-year probability of a major osteoporotic fracture (hip, spine, forearm, or upper arm)
  2. Your 10-year probability of a hip fracture specifically

It does this by combining your clinical risk factors -- with or without a bone density measurement -- into a single, evidence-based prediction.

You can access FRAX for free at: https://frax.shef.ac.uk/

FRAX helps answer the question: "Based on everything we know about you, how likely is a fracture in the next 10 years?"

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Walking through the FRAX calculator

The FRAX tool asks for specific information. Here is what each field means:

Country

Select your country of residence. FRAX adjusts its calculations based on the fracture and mortality rates specific to each country, so this is important for accuracy.

Age

Enter your current age. FRAX is validated for adults aged 40-90. Fracture risk increases significantly with age, even independent of bone density.

Sex

Select male or female. The calculation differs because women and men have different baseline fracture rates and risk factor profiles.

Weight and height

Enter your weight (in kg or lbs) and height (in cm or inches). FRAX uses these to calculate your BMI. A low BMI (below 20) is an independent risk factor for fracture.

Previous fracture

Have you broken a bone after age 40 from a fall from standing height or less (a "fragility fracture")? This includes vertebral compression fractures, even if they were painless and discovered incidentally on X-ray. A previous fracture is one of the strongest predictors of future fracture.

Parent fractured hip

Did either of your parents fracture their hip? Parental hip fracture history is a well-established genetic risk factor for osteoporosis and fracture.

Current smoking

Are you a current smoker? Smoking is directly harmful to bone cells, impairs calcium absorption, and increases fracture risk.

Glucocorticoids

Are you currently taking oral glucocorticoids (such as prednisone or prednisolone), or have you taken them for 3 or more months at a dose of 5 mg per day or more? Long-term glucocorticoid use is one of the most important secondary causes of osteoporosis.

Rheumatoid arthritis

Have you been diagnosed with rheumatoid arthritis (confirmed by a doctor)? RA is an independent risk factor for fracture, beyond any effect of corticosteroid treatment.

Secondary osteoporosis

Do you have any condition strongly associated with osteoporosis? This includes:

  • Type 1 (insulin-dependent) diabetes
  • Osteogenesis imperfecta
  • Long-standing untreated hyperthyroidism
  • Hypogonadism or premature menopause (before age 45)
  • Chronic malnutrition or malabsorption (e.g., celiac disease, Crohn's disease)
  • Chronic liver disease

Alcohol (3 or more units per day)

Do you drink 3 or more units of alcohol per day? (One unit is approximately a standard glass of beer, a medium glass of wine, or a single measure of spirits.) Heavy alcohol intake impairs bone formation and increases fall risk.

Bone mineral density (optional)

If you have had a DXA scan, you can enter your femoral neck T-score or BMD value. This makes the prediction more accurate, but FRAX can still provide a useful estimate without it.

You do not need a DXA scan to use FRAX. The tool works with clinical risk factors alone, making it useful as a first step.

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Understanding your results

After entering your information, FRAX provides two numbers:

10-year probability of major osteoporotic fracture

This is the percentage chance that you will experience a fracture of the hip, spine (clinical), forearm, or upper arm in the next 10 years. For example, a result of "15%" means that out of 100 people with your exact profile, approximately 15 would be expected to have a major osteoporotic fracture within 10 years.

10-year probability of hip fracture

This is the percentage chance of a hip fracture specifically. Hip fractures are singled out because they have the most severe consequences -- high rates of hospitalization, surgery, disability, and mortality.

What the numbers mean in practice

These are not certainties -- they are probabilities. A 15% risk does not mean you will definitely fracture; it means that your risk is higher than average and may warrant intervention.

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A practical example

Meet Margaret, a 68-year-old woman from the United States:

  • Weight: 58 kg (128 lbs), Height: 160 cm (5'3")
  • She fractured her wrist 3 years ago after slipping on ice
  • Her mother had a hip fracture at age 78
  • She does not smoke or drink heavily
  • She does not take glucocorticoids
  • Her femoral neck T-score is -2.1 (osteopenia)

Her FRAX results:

  • 10-year probability of major osteoporotic fracture: 23%
  • 10-year probability of hip fracture: 5.4%

Both values exceed the NOF treatment thresholds (20% major, 3% hip). Based on these results, Margaret's doctor would likely recommend starting osteoporosis treatment in addition to lifestyle measures, even though her DXA T-score is in the osteopenia range rather than osteoporosis.

This illustrates an important point: FRAX can identify people who need treatment even when their bone density alone would not qualify them.

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Important limitations of FRAX

FRAX is a valuable tool, but like all tools, it has limitations:

Dose-response is not captured

FRAX records risk factors as yes/no. It does not account for:

  • How many cigarettes you smoke (10 vs. 40 per day)
  • How long you have taken glucocorticoids (3 months vs. 10 years)
  • How much alcohol you drink beyond the 3-unit threshold
  • How many previous fractures you have had (1 vs. 5)

In reality, these dose-response relationships matter. Your doctor can make clinical adjustments when the simple yes/no does not capture the full picture.

Fall risk is not included

FRAX does not include fall risk as a variable, despite falls being the proximate cause of most fractures (except vertebral compression fractures). If you have a high fall risk -- due to balance problems, medication side effects, poor vision, or environmental hazards -- your actual fracture risk may be higher than FRAX estimates.

Spine DXA is not used

FRAX uses the femoral neck BMD only, not the lumbar spine. In some individuals, the spine T-score is significantly lower than the hip, and FRAX may underestimate their risk.

Not for people already on treatment

FRAX is designed for untreated individuals. If you are already taking osteoporosis medication, your FRAX score would underestimate your "untreated" risk.

Age range

FRAX is validated for ages 40-90. It should not be used for younger adults or for individuals over 90.

FRAX is an excellent starting point, but clinical judgment remains essential. Your doctor may adjust treatment decisions based on factors FRAX does not capture.

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Frequently Asked Questions

Q. Can I use FRAX on my own, or does my doctor need to do it?

You can access the FRAX calculator yourself at https://frax.shef.ac.uk/ and enter your information. However, interpreting the results and making treatment decisions should be done with your doctor, who can consider additional factors and explain what the numbers mean for your specific situation.

Q. I do not have a DXA scan result. Can I still use FRAX?

Yes. FRAX can calculate your fracture risk using clinical risk factors alone, without a BMD value. The result is slightly less precise, but still clinically useful. In fact, many guidelines recommend using FRAX as a first step to determine whether a DXA scan is needed.

Q. My FRAX score is below the treatment threshold. Does that mean I am safe?

A below-threshold FRAX score means your fracture risk is relatively low over the next 10 years, which is reassuring. However, risk factors can change over time (for example, if you start glucocorticoids, have a fracture, or develop a new medical condition). Periodic reassessment is sensible, particularly after age-related milestones or new health developments.

Q. Does FRAX work for men?

Yes. FRAX is validated for both men and women. While osteoporosis is more common in women, FRAX can identify men at elevated fracture risk and guide treatment decisions.

Q. My doctor calculated my FRAX score and it was borderline. What happens next?

If your FRAX score is near the treatment threshold, your doctor may recommend:

  • Getting a DXA scan (if you have not had one) to refine the estimate
  • Ordering a Vertebral Fracture Assessment (VFA) to check for silent spinal fractures
  • Reassessing in 1-2 years to see if your risk has changed
  • Focusing on lifestyle measures (exercise, calcium, vitamin D, fall prevention) while monitoring

Q. Is FRAX the only fracture risk assessment tool?

FRAX is the most widely used and validated tool globally, but others exist. In the UK, QFracture is an alternative that includes additional variables (such as falls and some medications). The Garvan Fracture Risk Calculator from Australia also incorporates fall history and number of prior fractures. Your doctor will use the tool most appropriate for your region and clinical situation.

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References

  • Kanis JA et al. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporosis International, 2008; 19: 385-397.
  • FRAX. WHO Fracture Risk Assessment Tool. Centre for Metabolic Bone Diseases, University of Sheffield. https://frax.shef.ac.uk/
  • Bone Health & Osteoporosis Foundation (BHOF). FRAX Fracture Risk Assessment Tool. https://www.bonehealthandosteoporosis.org/
  • National Osteoporosis Guideline Group (NOGG). Clinical Guideline for the Prevention and Treatment of Osteoporosis. https://www.nogg.org.uk/
  • Kanis JA et al. Interpretation and use of FRAX in clinical practice. Osteoporosis International, 2011; 22: 2395-2411.
  • Cosman F et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporosis International, 2014; 25: 2359-2381.
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Medical Supervision

Hiroyuki KatohOrthopedic Surgeon, Medical Registration No. 409723

Tokai University Hospital / Shoyo Kashiwadai Hospital

Last updated:March 21, 2026

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